U.S. Route 385 (Colorado)

U.S. Route 385
High Plains Highway
Map of eastern Colorado with US 385 highlighted in red
Route information
Maintained by CDOT
Length:	318.52 mi (512.61 km)
Existed:	1958 (1958) – present
Major junctions
South end:	US-287 / US-385 / SH-3 towards Boise City, OK
	US 50 / US 287 in Lamar US 40 in Cheyenne Wells I-70 in Burlington US 34 in Wray I-76 in Julesburg
North end:	US 385 towards Chappell, NE
Location
Counties:	Baca, Prowers, Kiowa, Cheyenne, Kit Carson, Yuma, Phillips, Sedgwick
Highway system
United States Numbered Highway System List Special Divided Replaced Colorado State Highways Interstate U.S. State Scenic ← SH 371 SH 389 →

U.S. Highway 385 (US 385), also known as the High Plains Highway north of Cheyenne Wells, is the easternmost significant north–south state highway in the U.S. state of Colorado. It enters the state from Oklahoma while overlapped with US 287, but splits at Lamar to follow its own route through the Eastern Plains to Nebraska.

US 385 is almost entirely a rural two-lane route. It begins at the Oklahoma state line on an overlap with US 287 (and at the west end of Oklahoma State Highway 3) and follows US 287 north through Campo and Springfield to Lamar. In that city it turns east with US 50 through Carlton to Granada, where the route turns north and finally separates from others. Communities along the route include Bristol, Sheridan Lake, Cheyenne Wells, Burlington, Wray, Holyoke, and Julesburg. US 385 turns west with US 138 in Julesburg, splitting west of the city and running northwest to the Nebraska state line.