U.S. Route 221 Business (Jefferson, North Carolina)

U.S. Route 221
Highway system
United States Numbered Highway System List Special Divided Replaced

U.S. Route 221 Truck
Location:	Perry, Florida
Length:	5.2 mi (8.4 km)

U.S. Highway 221 Truck
Location:	Hazlehurst, Georgia

U.S. Route 221 Truck
Location:	Laurens, South Carolina

U.S. Route 221 Alternate
Location:	Chesnee, SC–Rutherfordton, NC
Length:	26.2 mi (42.2 km)
Existed:	1941–present

U.S. Route 221 Business
Location:	Marion, North Carolina
Length:	5.0 mi (8.0 km)
Existed:	1991–present

U.S. Route 221 Truck
Location:	Linville–Boone, NC
Length:	16.9 mi (27.2 km)

U.S. Route 221 Business
Location:	West Jefferson–Jefferson, NC
Length:	4.4 mi (7.1 km)
Existed:	1981–present

U.S. Route 221 Business
Location:	Bedford, Virginia
Length:	2.9 mi (4.7 km)
Existed:	1999–present

Several special routes of U.S. Route 221 exist. In order from south to north they are as follows.

U.S. Route 221 Truck (US 221 Truck) directs truck drivers, that are passing through, to follow US 19 going northwest of Perry, then crosses back to US 221 via County Road 359A.

U.S. Route 221 Truck (US 221 Truck) directs truck drivers away from the local streets of Hazlehurst, Georgia, including the one-way pair section of US 221. It begins on East Jefferson Street from US 221 which is shared with US BUS 23/GA 135 Connector. When US BUS 23/SR Conn 135 ends at US 23/SR 19, US Truck 221/GA Truck 135 turn left onto the US 23/SR 19 overlap known as Larry Contos Boulevard, and then turns left onto US 341/SR 27 (Golden Isles Parkway) eventually terminating at northbound US 221 and the north end of US BUS 23. The route is entirely overlapped by Georgia Truck Route 135.

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