U.S. Route 221
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| Route information | |
| Auxiliary route of US 21 | |
| Length: | 734 mi (1,181 km) |
| Existed: | 1930 – present |
| Major junctions | |
| South end: |
      US 19 / US 27 Alt. / US 98 / SR 55 in Perry, FL
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 I-10 near Greenville, FL I‑75 in Valdosta, GA I‑16 near Soperton, GA I‑20 near Harlem, GA I-385 near Laurens, SC I-26 in Roebuck, SC I-85 in Spartanburg, SC I‑40 in Marion, NC I‑77 near Hillsville, VA I‑581 in Roanoke, VA
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| North end: |
      US 29 Bus. / US 460 Bus. / US 501 Bus. at Lynchburg, VA
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| Location | |
| States: | Florida, Georgia, South Carolina, North Carolina, Virginia |
| Highway system | |
U.S. Route 221 is a spur of U.S. Route 21. It runs for 734 miles (1,181 km) from Perry, Florida at U.S. Routes 19/98/27 Alternate to Lynchburg, Virginia at U.S. Route 29 (Lynchburg Expressway). It passes through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It goes through the cities of Valdosta, Georgia, Spartanburg, South Carolina, Marion, North Carolina, Roanoke, Virginia, and Lynchburg, Virginia.
Throughout western North Carolina from the Virginia border to the Blue Ridge Parkway, U.S. 221 is a challenging drive, and can be described as one climb after another. There are few places where the road builders attempted to skirt around large foothills.
U.S. Route 221 originates just south of the city of Perry with its southern terminus intersecting with the cosigned U.S. Route 19 U.S. Route 98 and U.S. Route 27 Alternate, taking hidden SR 55 with it away from US 19. It continues through the city of Perry and intersects Interstate 10 and U.S. Route 90 in rural Madison County before crossing into Georgia.
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Wikipedia