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Trace amine-associated receptor 1

TAAR1
Identifiers
Aliases TAAR1, TA1, TAR1, TRAR1, trace amine associated receptor 1
External IDs MGI: 2148258 HomoloGene: 24938 GeneCards: TAAR1
Targeted by Drug
phenethylamine, dextroamphetamine, octopamine, R(-)amphetamine, RO5166017, tyramine, EPPTB, 2-phenylpropylamine, dopamine, amphetamine
RNA expression pattern
PBB GE TAAR1 gnf1h10289 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138327

NM_053205

RefSeq (protein)

NP_612200

NP_444435.1
NP_444435

Location (UCSC) Chr 6: 132.64 – 132.65 Mb Chr 10: 23.92 – 23.92 Mb
PubMed search

NM_138327

NM_053205

NP_612200

NP_444435.1
NP_444435

Trace amine-associated receptor 1 (TAAR1) is a protein that in humans is encoded by the TAAR1 gene. TAAR1 is an amine-activated Gs-coupled and Gq-coupled G protein-coupled receptor (GPCR) that is primarily located in several peripheral organs, lymphocytes, astrocytes, and in the intracellular compartments within the presynaptic plasma membrane (i.e., axon terminal) of monoamine neurons in the central nervous system (CNS). TAAR1 was discovered in 2001 by two independent groups of investigators, Borowski et al. and Bunzow et al. TAAR1 is one of six functional trace amine-associated receptors in humans, which are so named for their ability to bind endogenous amines that occur in tissues at trace concentrations. TAAR1 plays a significant role in regulating neurotransmission in dopamine, norepinephrine, and serotonin neurons in the CNS; it also affects immune system and neuroimmune system function through different mechanisms.


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