Beginning in the second half of the 16th century, the Kingdom of Spain established a number of missions throughout La Florida in order to convert the Indians to Christianity, to facilitate control of the area, and to prevent its colonization by other countries, in particular, England and France. Spanish Florida originally included much of what is now the Southeastern United States, although Spain never exercised long-term effective control over more than the northern part of what is now the State of Florida from present-day St. Augustine to the area around Tallahassee, southeastern Georgia, and some coastal settlements, such as Pensacola, Florida. A few short-lived missions were established in other locations, including Mission Santa Elena in present-day South Carolina, around the Florida peninsula, and in the interior of Georgia and Alabama.
The missions of what are now northern Florida and southeastern Georgia were divided into main four provinces where the bulk of missionary effort took place. These were Apalachee, comprising the eastern part of what is now the Florida Panhandle; Timucua, ranging from the St. Johns River west to the Suwanee; Mocama, the coastal areas east of the St. Johns running north to the Altamaha River; and Guale, north of the Altamaha River along the coast to the present-day Georgia Sea Islands. These provinces roughly corresponded to the areas where those dialects were spoken among the varying Native American peoples, thus, they reflected the territories of the peoples. Missionary provinces were relatively fluid and evolved over the years according to demographic and political trends, and at various times smaller provinces were established, abandoned, or merged with larger ones. There were also ephemeral attempts to establish missions elsewhere, particularly further south into Florida.