Santa Elena, a Spanish settlement on what is now Parris Island, South Carolina, was the capital of Spanish Florida from 1566 to 1587. It was established under Pedro Menéndez de Avilés, the first governor of Spanish Florida. There had been a number of earlier attempts to establish colonies in the area by both the Spanish and the French, who had been inspired by earlier accounts of the plentiful land of Chicora. Menéndez's Santa Elena settlement was intended as the new capital of the Spanish colony of La Florida, shifting the focus of Spanish colonial efforts north from St. Augustine, which had been established in 1565 to oust the French from their colony of Fort Caroline. Santa Elena was ultimately built at the site of the abandoned French outpost of Charlesfort, founded in 1562 by Jean Ribault.
Santa Elena followed the destruction of the French Fort Caroline by Menéndez in 1565. The settlement housed a sizeable community, and became the base of operations for the Jesuits and military working in the northern zone of Spanish Florida. From this base the Spanish founded a number of other ephemeral forts as far inland as the Appalachian Mountains, but resistance from local Native American tribes and the lack of interest of Spain in the area, caused these to be abandoned, relocated or destroyed. Santa Elena was ultimately abandoned in 1587, with its survivors relocating to St. Augustine. The Spanish never pressed their colonial claims to the area again, focusing on other areas of the American continent.
Interest in the area was piqued following exploration of some part of what is now the coastal southeastern United States by Francisco Gordillo and Pedro de Quejo in 1521. Accounts of the region's abundance from Quejo and Francisco de Chicora, one of the 70 Indians the expedition brought to Hispaniola, inspired Lucas Vázquez de Ayllón to establish the short-lived colony of San Miguel de Gualdape. This was abandoned after only a few months. In 1540 Hernando de Soto's expedition found European goods in the wealthy town of Cofitachequi, and thus determined they were near the site of Ayllón's colony; their accounts of the wealthy land inspired further colonial ambitions. In 1559, Tristán de Luna y Arellano established a settlement at present-day Pensacola, Florida as a base for future colonization of Santa Elena, but this mission failed. The French also heard the early accounts and took an interest in the area; in 1562 Jean Ribault came to Parris Island and set up the short-lived settlement of Charlesfort there. However, this was abandoned the following year.