Francisco de Chicora was the baptismal name given to a Native American kidnapped in 1521, along with 70 others, from near the mouth of the Pee Dee River by Spanish explorer Francisco Gordillo and slave trader Pedro de Quexos, based in Santo Domingo and the first Europeans to reach the area. From analysis of the account by Peter Martyr, court chronicler, the ethnographer John R. Swanton believed that Chicora was from a Catawban group.
In Hispaniola, where he and the other captives were taken, Chicora learned Spanish, was baptized a Catholic, and worked for Lucas Vasquez de Ayllón, a colonial official. Most of the natives died within two years. Accompanying Ayllón to Spain, de Chicora met with the chronicler Peter Martyr and told him much about his people. Martyr combined this information with accounts by explorers and recorded it as the "Testimony of Francisco de Chicora," published with his seventh Decade in 1525. In 1526 Chicora accompanied Ayllón on a major expedition to North America with 600 colonists. After they struck land at the Santee River and the party went ashore, Chicora escaped and returned to his people.
The Spanish had made repeated expeditions to the southeastern part of what is now the United States, where they explored areas around the Santee River in present-day South Carolina and Winyah Bay and other areas.Lucas Vázquez de Ayllón, oidor (judge) of the royal Audencia of Santa Domingo, commissioned Francisco Gordillo to make an expedition to the continent in 1520. Gordillo sailed north from Hispaniola through the Bahamas, where near the island of Lucayoneque he fell in with a caravel commanded by the slave raider Pedro de Quexos (Pedro de Quejo), who was trying to capture Arawak to sell as slaves, without success. Quexos happened to be a relative of Gordillo's pilot Alonzo Fernandez Sotil, and decided to join Gordilla's expedition, and in June 1521 the two struck land at what they called the River of San Juan Bautista (St. John the Baptist), probably the Pee Dee in present-day South Carolina. A crowd of curious natives gathered on the shore to watch the strangers. The natives fled when the Spanish approached in shallops, but two were caught, taken aboard a ship, given Spanish clothes, and returned ashore. The natives again swarmed the beach, seeing their comrades' return and changed appearance as a wondrous sign, since they had worn only buckskins before. The chief ordered 50 of his subjects to bring food for the Spanish. Once ashore, the Spanish were given presents and a guided tour for several days. They claimed the land for their king, and invited the natives aboard to see their ships.