TREM2

TREM2
Identifiers
Aliases	TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2
External IDs	MGI: 1913150 HomoloGene: 10352 GeneCards: TREM2
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 41,158,506 bp End 41,163,186 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 C Start 48,346,401 bp End 48,354,147 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • scaffold protein binding • lipopolysaccharide binding • lipoteichoic acid binding • peptidoglycan binding • receptor activity • phospholipid binding Cellular component • integral component of membrane • membrane • extracellular region • plasma membrane Biological process • dendritic cell differentiation • positive regulation of CD40 signaling pathway • positive regulation of calcium-mediated signaling • positive regulation of C-C chemokine receptor CCR7 signaling pathway • phagocytosis, engulfment • detection of peptidoglycan • humoral immune response • cellular response to lipoteichoic acid • positive regulation of protein localization to plasma membrane • regulation of immune response • positive regulation of peptidyl-tyrosine phosphorylation • detection of lipoteichoic acid • innate immune response • detection of lipopolysaccharide • cellular response to peptidoglycan • positive regulation of antigen processing and presentation of peptide antigen via MHC class II • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54209	83433
Ensembl	ENSG00000095970	ENSMUSG00000023992
UniProt	Q9NZC2	Q99NH8
RefSeq (mRNA)	NM_001271821 NM_018965	NM_001272078 NM_031254
RefSeq (protein)	NP_001258750 NP_061838	NP_001259007 NP_112544
Location (UCSC)	Chr 6: 41.16 – 41.16 Mb	Chr 6: 48.35 – 48.35 Mb
PubMed search

54209

83433

ENSG00000095970

ENSMUSG00000023992

Q9NZC2

Q99NH8

NM_001271821
NM_018965

NM_001272078
NM_031254

NP_001258750
NP_061838

NP_001259007
NP_112544

Triggering receptor expressed on myeloid cells 2 also known as TREM-2 is a protein that in humans is encoded by the TREM2 gene.

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1), Fc receptors, CD14 and Toll-like receptors (e.g., TLR4), and cytokine receptors (e.g., IFNGR1). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Immunoglobulin (Ig) superfamily, such as TREM2, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1) or inhibitory functions (e.g., KIR2DL1).

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Wikipedia