CD14

CD14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GLP
Identifiers
Aliases	CD14, entrez:929
External IDs	OMIM: 158120 MGI: 88318 HomoloGene: 493 GeneCards: CD14
Gene ontology Molecular function • lipopolysaccharide binding • opsonin receptor activity • lipoteichoic acid binding • protein binding • peptidoglycan receptor activity Cellular component • Golgi apparatus • membrane • plasma membrane • extracellular region • cell surface • lipopolysaccharide receptor complex • anchored component of external side of plasma membrane • membrane raft • anchored component of membrane • endosome membrane • extracellular exosome • external side of plasma membrane • extracellular space • secretory granule membrane Biological process • toll-like receptor TLR1:TLR2 signaling pathway • response to bacterium • toll-like receptor 4 signaling pathway • immune system process • positive regulation of cytokine secretion • cellular response to diacyl bacterial lipopeptide • positive regulation of interferon-gamma production • response to magnesium ion • response to heat • response to electrical stimulus • MyD88-dependent toll-like receptor signaling pathway • receptor-mediated endocytosis • cellular response to triacyl bacterial lipopeptide • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • positive regulation of endocytosis • cell surface receptor signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • phagocytosis • positive regulation of tumor necrosis factor production • inflammatory response • response to ethanol • I-kappaB kinase/NF-kappaB signaling • toll-like receptor TLR6:TLR2 signaling pathway • cellular response to lipopolysaccharide • response to molecule of bacterial origin • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • MyD88-independent toll-like receptor signaling pathway • apoptotic process • innate immune response • necroptotic process • negative regulation of MyD88-independent toll-like receptor signaling pathway • apoptotic signaling pathway • toll-like receptor signaling pathway • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	929	12475
Ensembl	ENSG00000170458	ENSMUSG00000051439
UniProt	P08571	P10810
RefSeq (mRNA)	NM_001174105 NM_000591 NM_001040021 NM_001174104	NM_009841
RefSeq (protein)	NP_000582 NP_001035110 NP_001167575 NP_001167576	NP_033971.1 NP_033971
Location (UCSC)	Chr 5: 140.63 – 140.63 Mb	Chr 18: 36.73 – 36.73 Mb
PubMed search

4GLP

929

12475

ENSG00000170458

ENSMUSG00000051439

P08571

P10810

NM_001174105
NM_000591
NM_001040021
NM_001174104

NM_009841

NP_000582
NP_001035110
NP_001167575
NP_001167576

NP_033971.1
NP_033971

CD14 (cluster of differentiation 14), also known as CD14, is a human gene.

The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).

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