TGFB2

TGFB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TFG, 2TGI, 4KXZ
Identifiers
Aliases	TGFB2, LDS4, TGF-beta2, transforming growth factor beta 2
External IDs	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Genetically Related Diseases
chronic obstructive pulmonary disease
Gene ontology Molecular function • type II transforming growth factor beta receptor binding • receptor binding • type III transforming growth factor beta receptor binding • cytokine activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • transforming growth factor beta receptor binding • growth factor activity • protein homodimerization activity • beta-amyloid binding • protein binding • protein heterodimerization activity Cellular component • endosome • extracellular region • extracellular matrix • axon • neuronal cell body • platelet alpha granule lumen • extracellular space Biological process • eye development • hemopoiesis • regulation of transforming growth factor beta2 production • embryo development • response to progesterone • cell death • cardioblast differentiation • positive regulation of integrin biosynthetic process • protein phosphorylation • positive regulation of heart contraction • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • blood vessel remodeling • positive regulation of neuron apoptotic process • blood vessel development • angiogenesis • negative regulation of epithelial cell proliferation • uterine wall breakdown • negative regulation of alkaline phosphatase activity • hair follicle morphogenesis • negative regulation of macrophage cytokine production • positive regulation of cell adhesion mediated by integrin • positive regulation of activation-induced cell death of T cells • cell proliferation • transforming growth factor beta receptor signaling pathway • face morphogenesis • negative regulation of cell proliferation • positive regulation of stress-activated MAPK cascade • regulation of apoptotic process • pathway-restricted SMAD protein phosphorylation • cell-cell junction organization • SMAD protein signal transduction • extrinsic apoptotic signaling pathway • SMAD protein import into nucleus • collagen fibril organization • positive regulation of epithelial cell migration • neuron development • negative regulation of gene expression • neutrophil chemotaxis • cell growth • heart development • positive regulation of cell growth • positive regulation of cell cycle • response to wounding • negative regulation of cell growth • positive regulation of cardioblast differentiation • glial cell migration • hair follicle development • regulation of actin cytoskeleton organization • negative regulation of cartilage development • dopamine biosynthetic process • wound healing • positive regulation of ossification • cardiac muscle cell proliferation • positive regulation of epithelial to mesenchymal transition • odontogenesis • positive regulation of catagen • positive regulation of immune response • regulation of complement-dependent cytotoxicity • positive regulation of protein secretion • epithelial to mesenchymal transition • catagen • embryonic digestive tract development • cartilage condensation • positive regulation of protein localization to nucleus • response to hypoxia • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • somatic stem cell division • heart morphogenesis • platelet degranulation • positive regulation of GTP binding • salivary gland morphogenesis • generation of neurons • axon guidance • positive regulation of extracellular matrix disassembly • positive regulation of gene expression • negative regulation of immune response • cell cycle arrest • cell morphogenesis • positive regulation of cell proliferation • regulation of extracellular matrix organization • positive regulation of phosphatidylinositol 3-kinase signaling • neuron fate commitment • cell migration • activation of protein kinase activity • positive regulation of cell division • response to drug • cardiac epithelial to mesenchymal transition • signal transduction by protein phosphorylation • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • endocardial cushion morphogenesis • extracellular matrix organization • negative regulation of Ras protein signal transduction • heart valve morphogenesis • skeletal system development • kidney development • neural tube closure • outflow tract septum morphogenesis • membranous septum morphogenesis • atrioventricular valve morphogenesis • pulmonary valve morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • endocardial cushion fusion • atrial septum primum morphogenesis • neural retina development • male gonad development • embryonic limb morphogenesis • ascending aorta morphogenesis • inner ear development • palate development • uterus development • ventricular septum morphogenesis • atrial septum morphogenesis • pharyngeal arch artery morphogenesis • regulation of apoptotic process involved in outflow tract morphogenesis • substantia propria of cornea development • cranial skeletal system development • BMP signaling pathway • cell development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7042	21808
Ensembl	ENSG00000092969	ENSMUSG00000039239
UniProt	P61812	P27090
RefSeq (mRNA)	NM_003238 NM_001135599	NM_009367 NM_001329107
RefSeq (protein)	NP_001129071 NP_003229	NP_033393.2 NP_001316036 NP_033393
Location (UCSC)	Chr 1: 218.35 – 218.44 Mb	Chr 1: 186.62 – 186.71 Mb
PubMed search

1TFG, 2TGI, 4KXZ

7042

21808

ENSG00000092969

ENSMUSG00000039239

P61812

P27090

NM_003238
NM_001135599

NM_009367
NM_001329107

NP_001129071
NP_003229

NP_033393.2
NP_001316036
NP_033393

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

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