TACI

TNFRSF13B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XU1, 1XUT
Identifiers
Aliases	TNFRSF13B, CD267, CVID, CVID2, RYZN, TACI, TNFRSF14B, IGAD2, tumor necrosis factor receptor superfamily member 13B, TNF receptor superfamily member 13B
External IDs	MGI: 1889411 HomoloGene: 49320 GeneCards: TNFRSF13B
Gene ontology Molecular function • protein binding • receptor activity Cellular component • integral component of membrane • integral component of plasma membrane • external side of plasma membrane • membrane • plasma membrane Biological process • cell surface receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • adaptive immune response • immune system process • hematopoietic progenitor cell differentiation • negative regulation of B cell proliferation • B cell homeostasis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23495	57916
Ensembl	ENSG00000240505	ENSMUSG00000010142
UniProt	O14836	Q9ET35
RefSeq (mRNA)	NM_012452	NM_021349
RefSeq (protein)	NP_036584	NP_067324
Location (UCSC)	Chr 17: 16.93 – 16.97 Mb	Chr 11: 61.13 – 61.15 Mb
PubMed search

1XU1, 1XUT

23495

57916

ENSG00000240505

ENSMUSG00000010142

O14836

Q9ET35

NM_012452

NM_021349

NP_036584

NP_067324

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene

TNFRSF13B is a transmembrane protein of the TNF receptor superfamily found predominantly on the surface of B cells, which are an important part of the immune system. TACI recognizes three ligands: APRIL, BAFF and CAML.

TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases and has shown to cause fatal autoimmunity in mice.

...
Wikipedia