CAMLG

CAMLG
Identifiers
Aliases	CAMLG, CAML, GET2, calcium modulating ligand
External IDs	MGI: 104728 HomoloGene: 1323 GeneCards: CAMLG
Gene ontology Molecular function • protein binding • cell adhesion molecule binding Cellular component • integral component of membrane • endoplasmic reticulum • membrane Biological process • defense response • viral process • receptor recycling • epidermal growth factor receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	819	12328
Ensembl	ENSG00000164615	ENSMUSG00000021501
UniProt	P49069	P49070
RefSeq (mRNA)	NM_001745	NM_007596
RefSeq (protein)	NP_001736	NP_031622
Location (UCSC)	Chr 5: 134.74 – 134.75 Mb	Chr 13: 55.62 – 55.63 Mb
PubMed search

819

12328

ENSG00000164615

ENSMUSG00000021501

P49069

P49070

NM_001745

NM_007596

NP_001736

NP_031622

Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI.

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

CAMLG has been shown to interact with TNFRSF13B.

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Wikipedia