Sredorek (Macedonian: Средорек) is a historical and geographical region in northeastern Republic of Macedonia. It includes settlements in the Pčinja river valley, parts of the mountainous regions of Kozjak (Kozjačija), German and Rujen, which are today located within the Municipality of Staro Nagoričane. The region is predominantly inhabited by ethnic Macedonians and ethnic Serbs (see Serbs in the Republic of Macedonia), adherents of Eastern Orthodoxy. In the Middle Ages, the region was part of the župe (counties) of Žegligovo and Preševo.
Notable monuments in the region include the Church of St. George,
The region includes settlements in the Pčinja river valley, parts of the mountainous regions of Kozjak (Kozjačija), German, Rujen, which are today located within the Municipality of Staro Nagoričane; roughly from Pčinja and the lower course of the Kriva Reka. The region borders Serbia to the north, and the historical and geographical regions of Slavište and Stracin.