Sky Regional Airlines is an airline whose corporate headquarters is on the property of Toronto Pearson International Airport, Mississauga, Ontario, Canada. Linked with Skyservice Business Aviation, it began operation under the Air Canada Express brand on May 1, 2011. The airline began offering daily flights between Toronto Island and Montréal–Pierre Elliott Trudeau International Airport.

In October 2012, Sky Regional added flights between Montreal and Moncton, New Brunswick. Since the early stages of operation the airline has been active in introducing new technology to its operation. Sky Regional was the first airline in Canada to adopt the Electronic Flight Bag (EFB). Each pilot at the company is issued an Apple iPad which is the platform for the EFB allowing crews to not only have quick access to flight plans and manuals but eliminate paper charts and numerous large manuals which previously would have been present on the flight deck.

Sky Regional introduced a fleet of Embraer 175 jets in March 2013 to serve US destinations such as New York, Newark, Boston, Philadelphia, Chicago, and Dallas/Fort Worth.

Between October and December 2015 the fleet of 20 was expanded to 25 after obtaining 5 additional Embraer 175 previously operated by Azul Brazilian Airlines. These aircraft were put into service in April 2016 allowing the airline to add routes to more US destination such as Denver International Airport, and Hartsfield-Jackson Atlanta International Airport.

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