War between the Seleucid Empire and the Ptolemaic Kingdom seems to have allowed Sames an opportunity of independence. What side he took in the Syrian Wars is unknown as most of the records of that era have been lost, though it would make sense that he would have supported the Ptolemaic Kingdom against his large and powerful neighbour, the Seleucid Empire.

Most sources give Orontes III as his father. After Orontes III died in 260 BC, there is no record for when Sames began his rule, only his year of death, in 260 BC as well. This seems to be blundered, chronologically. It may be that Sames was meant to succeed Orontes IV, but died the same year. That they both died in the same year looks suspicious, and may have been a Seleucid plot to take control, however it seems Arsames I took control of Commagene, Sophene and Armenia after 260 AD, and even that makes him look suspect.

Commagene was outside the boundary of historic Armenia, yet the Armenian satraps remained in occupation of many regions of Anatolia, such as Cappadocia and Pontus. It may have been that the son and heir to the Armenian kingdom would rule another region, just as the son or heir to the Achaemenid Empire had always ruled an outlying region, such as Bactria or Hyrkania. Viewing it from this perspective it would make sense, as his father Orontes III was of the Orontid family.

It is suggested that Samos founded the city of Samosata, which has been submerged by the Ataturk Dam since 1989.

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Wikipedia