SREBF2

SREBF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UKL
Identifiers
Aliases	SREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2
External IDs	MGI: 107585 HomoloGene: 20966 GeneCards: SREBF2
Gene location (Human) Chr. Chromosome 22 (human) Band No data available Start 41,833,079 bp End 41,907,308 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band No data available Start 82,147,266 bp End 82,205,376 bp
Gene ontology Molecular function • C-8 sterol isomerase activity • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • E-box binding • protein C-terminus binding • protein binding • transcription regulatory region DNA binding Cellular component • cytoplasm • integral component of membrane • cytosol • SREBP-SCAP-Insig complex • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • cytoplasmic vesicle • nucleus • nucleoplasm • mitochondrion • intracellular membrane-bounded organelle Biological process • regulation of cholesterol homeostasis • steroid metabolic process • regulation of transcription, DNA-templated • positive regulation of protein targeting to mitochondrion • lipid metabolic process • positive regulation of cholesterol storage • cellular response to laminar fluid shear stress • cellular response to starvation • regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter • cholesterol metabolic process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of autophagy of mitochondrion • negative regulation of cholesterol efflux • response to low-density lipoprotein particle stimulus • positive regulation of transcription from RNA polymerase II promoter • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6721	20788
Ensembl	ENSG00000198911	ENSMUSG00000022463
UniProt	Q12772	Q3U1N2
RefSeq (mRNA)	NM_004599	NM_033218
RefSeq (protein)	NP_004590	NP_150087
Location (UCSC)	Chr 22: 41.83 – 41.91 Mb	Chr 22: 82.15 – 82.21 Mb
PubMed search

1UKL

6721

20788

ENSG00000198911

ENSMUSG00000022463

Q12772

Q3U1N2

NM_004599

NM_033218

NP_004590

NP_150087

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.

SREBF2 has been shown to interact with INSIG1 and CREB-binding protein.

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Wikipedia