INSIG1

INSIG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J81
Identifiers
Aliases	INSIG1, CL-6, CL6, insulin induced gene 1
External IDs	MGI: 1916289 HomoloGene: 4047 GeneCards: INSIG1
Gene location (Human) Chr. Chromosome 7 (human) Band No data available Start 155,297,776 bp End 155,310,235 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 28,071,363 bp End 28,078,662 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • SREBP-SCAP-Insig complex • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • palate development • steroid metabolic process • negative regulation of fat cell differentiation • sterol biosynthetic process • negative regulation of fatty acid biosynthetic process • lipid metabolic process • cholesterol metabolic process • response to sterol depletion • cranial suture morphogenesis • negative regulation of cargo loading into COPII-coated vesicle • inner ear morphogenesis • middle ear morphogenesis • SREBP signaling pathway • cholesterol biosynthetic process • metabolic process • cell proliferation • triglyceride metabolic process • negative regulation of steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3638	231070
Ensembl	ENSG00000186480	ENSMUSG00000045294
UniProt	O15503	Q8BGI3
RefSeq (mRNA)	NM_001346590 NM_001346591 NM_001346592 NM_001346593 NM_001346594 NM_005542 NM_198336 NM_198337	NM_153526
RefSeq (protein)	NP_001333519 NP_001333520 NP_001333521 NP_001333522 NP_001333523 NP_005533 NP_938150 NP_938151	NP_705746
Location (UCSC)	Chr 7: 155.3 – 155.31 Mb	Chr 7: 28.07 – 28.08 Mb
PubMed search

4J81

3638

231070

ENSG00000186480

ENSMUSG00000045294

O15503

Q8BGI3

NM_005542
NM_198336
NM_198337

NM_153526

NP_005533
NP_938150
NP_938151

NP_705746

Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene.

INSIG1 is short for insulin-induced gene 1; it is located on chromosome 7 (7q36). This human gene encodes for a 277 AA long transmembrane protein with probably 6 transmembrane domains. It is localized in the ER and seems to be expressed in all tissues, especially in liver.

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