SPRED2

SPRED2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JP2
Identifiers
Aliases	SPRED2, Spred-2, sprouty related EVH1 domain containing 2
External IDs	MGI: 2150019 HomoloGene: 24918 GeneCards: SPRED2
Genetically Related Diseases
rheumatoid arthritis, celiac disease
Gene ontology Molecular function • protein binding • protein kinase binding • protein serine/threonine kinase inhibitor activity • stem cell factor receptor binding Cellular component • cytoplasm • plasma membrane • transport vesicle membrane • membrane • cytoplasmic vesicle • cytosol Biological process • multicellular organism development • negative regulation of peptidyl-threonine phosphorylation • regulation of signal transduction • fibroblast growth factor receptor signaling pathway • regulation of protein deacetylation • inactivation of MAPK activity • positive regulation of DNA damage response, signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	200734	114716
Ensembl	ENSG00000198369	ENSMUSG00000045671
UniProt	Q7Z698	Q924S7
RefSeq (mRNA)	NM_001128210 NM_181784	NM_033523
RefSeq (protein)	NP_001121682 NP_861449	NP_277058.1 NP_277058
Location (UCSC)	Chr 2: 65.31 – 65.43 Mb	Chr 11: 19.92 – 20.02 Mb
PubMed search

2JP2

200734

114716

ENSG00000198369

ENSMUSG00000045671

Q7Z698

Q924S7

NM_001128210
NM_181784

NM_033523

NP_001121682
NP_861449

NP_277058.1
NP_277058

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1).

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Wikipedia