SMAD anchor for receptor activation

ZFYVE9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1DEV, 1MK2, 4BKW
Identifiers
Aliases	ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs	MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9
Gene location (Human) Chr. Chromosome 1 (human) Band 1p32.3 Start 52,142,094 bp End 52,346,686 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C7 Start 108,637,466 bp End 108,780,798 bp
Gene ontology Molecular function • 1-phosphatidylinositol binding • serine-type peptidase activity • protein binding • metal ion binding • protein domain specific binding Cellular component • cytoplasm • endosome • early endosome • early endosome membrane • membrane • cytosol • intracellular membrane-bounded organelle • macromolecular complex Biological process • endocytosis • transforming growth factor beta receptor signaling pathway • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9372	230597
Ensembl	ENSG00000157077	ENSMUSG00000034557
UniProt	O95405	n/a
RefSeq (mRNA)	NM_004799 NM_007323 NM_007324	NM_183300 NM_001347163
RefSeq (protein)	NP_004790 NP_015563	n/a
Location (UCSC)	Chr 1: 52.14 – 52.35 Mb	Chr 4: 108.64 – 108.78 Mb
PubMed search

1DEV, 1MK2, 4BKW

9372

230597

ENSG00000157077

ENSMUSG00000034557

O95405

n/a

NM_004799
NM_007323
NM_007324

NM_183300
NM_001347163

NP_004790
NP_015563

n/a

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene. SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

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