SMAD2

SMAD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DEV, 1KHX, 1U7V, 2LB3
Identifiers
Aliases	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2
External IDs	OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2
Gene ontology Molecular function • phosphatase binding • I-SMAD binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • enhancer binding • R-SMAD binding • co-SMAD binding • transcription factor binding • activating transcription factor binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • chromatin binding • protein binding • double-stranded DNA binding • SMAD binding • DNA binding • protein heterodimerization activity • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • nucleus • SMAD2-SMAD3 protein complex • nuclear chromatin • SMAD protein complex • transcription factor complex • intracellular • nucleoplasm • protein complex • activin responsive factor complex Biological process • pattern specification process • ureteric bud development • endoderm development • response to cholesterol • organ growth • embryonic pattern specification • zygotic specification of dorsal/ventral axis • post-embryonic development • protein phosphorylation • pericardium development • regulation of binding • transforming growth factor beta receptor signaling pathway • negative regulation of cell proliferation • cell fate commitment • common-partner SMAD protein phosphorylation • regulation of transcription, DNA-templated • SMAD protein signal transduction • lung development • signal transduction involved in regulation of gene expression • insulin secretion • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • nodal signaling pathway • positive regulation of transcription, DNA-templated • heart development • pancreas development • endoderm formation • activin receptor signaling pathway • SMAD protein complex assembly • palate development • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • embryonic foregut morphogenesis • negative regulation of transcription from RNA polymerase II promoter • response to glucose • positive regulation of epithelial to mesenchymal transition • developmental growth • gastrulation • primary miRNA processing • positive regulation of BMP signaling pathway • embryonic cranial skeleton morphogenesis • negative regulation of transcription, DNA-templated • paraxial mesoderm morphogenesis • intracellular signal transduction • somatic stem cell population maintenance • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of gene expression • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription from RNA polymerase II promoter • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4087	17126
Ensembl	ENSG00000175387	ENSMUSG00000024563
UniProt	Q15796	Q62432
RefSeq (mRNA)	NM_001003652 NM_001135937 NM_005901	NM_001252481 NM_010754 NM_001311070
RefSeq (protein)	NP_001003652 NP_001129409 NP_005892	NP_001239410.1 NP_001297999.1 NP_034884.2 NP_001239410 NP_001297999 NP_034884
Location (UCSC)	Chr 18: 47.81 – 47.93 Mb	Chr 18: 76.24 – 76.31 Mb
PubMed search

1DEV, 1KHX, 1U7V, 2LB3

4087

17126

ENSG00000175387

ENSMUSG00000024563

Q15796

Q62432

NM_001003652
NM_001135937
NM_005901

NM_001252481
NM_010754
NM_001311070

NP_001003652
NP_001129409
NP_005892

NP_034884

Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

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