SMAD3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ

Identifiers

Aliases

SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3

External IDs

OMIM: 603109 MGI: 1201674 HomoloGene: 55937 GeneCards: SMAD3

Genetically Related Diseases

inflammatory bowel disease, Crohn's disease, asthma, coronary artery disease

Gene ontology
Molecular function	• phosphatase binding • transcription factor activity, sequence-specific DNA binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • enhancer binding • RNA polymerase II activating transcription factor binding • transcription regulatory region DNA binding • R-SMAD binding • co-SMAD binding • transcription factor activity, protein binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • enzyme binding • transforming growth factor beta receptor binding • protein homodimerization activity • collagen binding • zinc ion binding • chromatin binding • core promoter proximal region sequence-specific DNA binding • protein binding • double-stranded DNA binding • SMAD binding • protein kinase binding • sequence-specific DNA binding • DNA binding • bHLH transcription factor binding • ubiquitin binding • identical protein binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • beta-catenin binding • transcription factor activity, RNA polymerase II core promoter sequence-specific
Cellular component	• cytoplasm • nucleus • SMAD2-SMAD3 protein complex • nuclear chromatin • SMAD protein complex • transcription factor complex • receptor complex • plasma membrane • intracellular • nucleoplasm • protein complex • nuclear inner membrane • cytosol
Biological process	• somitogenesis • skeletal system development • ureteric bud development • endoderm development • regulation of transforming growth factor beta2 production • embryonic pattern specification • regulation of transcription from RNA polymerase II promoter • negative regulation of osteoblast differentiation • heart looping • positive regulation of chondrocyte differentiation • positive regulation of alkaline phosphatase activity • positive regulation of interleukin-1 beta production • pericardium development • regulation of binding • negative regulation of wound healing • activation of cysteine-type endopeptidase activity involved in apoptotic process • transforming growth factor beta receptor signaling pathway • negative regulation of inflammatory response • positive regulation of positive chemotaxis • negative regulation of cell proliferation • negative regulation of fat cell differentiation • cell-cell junction organization • regulation of transcription, DNA-templated • SMAD protein signal transduction • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • signal transduction involved in regulation of gene expression • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • nodal signaling pathway • positive regulation of transcription, DNA-templated • negative regulation of cell growth • regulation of immune response • positive regulation of transforming growth factor beta3 production • T cell activation • activin receptor signaling pathway • regulation of striated muscle tissue development • SMAD protein complex assembly • embryonic foregut morphogenesis • positive regulation of bone mineralization • wound healing • negative regulation of apoptotic process • positive regulation of extracellular matrix assembly • negative regulation of transcription from RNA polymerase II promoter • positive regulation of epithelial to mesenchymal transition • positive regulation of transcription factor import into nucleus • evasion or tolerance of host defenses by virus • thyroid gland development • developmental growth • lens fiber cell differentiation • gastrulation • immune response • osteoblast differentiation • transport • primary miRNA processing • negative regulation of osteoblast proliferation • osteoblast development • embryonic cranial skeleton morphogenesis • transdifferentiation • paraxial mesoderm morphogenesis • response to hypoxia • positive regulation of cell migration • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of gene expression • immune system development • cell cycle arrest • positive regulation of focal adhesion assembly • liver development • regulation of epithelial cell proliferation • positive regulation of stress fiber assembly • positive regulation of transcription from RNA polymerase II promoter • negative regulation of mitotic cell cycle • positive regulation of catenin import into nucleus • negative regulation of cytosolic calcium ion concentration • canonical Wnt signaling pathway • protein stabilization • transcription, DNA-templated • negative regulation of protein catabolic process • protein deubiquitination • positive regulation of nitric oxide biosynthetic process • negative regulation of lung blood pressure • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of cardiac muscle hypertrophy in response to stress
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4088


17127

Ensembl


ENSG00000166949


ENSMUSG00000032402

UniProt


P84022


Q8BUN5

RefSeq (mRNA)


NM_001145102 NM_001145103 NM_001145104 NM_005902


NM_016769

RefSeq (protein)


NP_001138574 NP_001138575 NP_001138576 NP_005893


NP_058049.3 NP_058049

Location (UCSC)

Chr 15: 67.06 – 67.2 Mb

Chr 9: 63.65 – 63.76 Mb

PubMed search

2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ

NM_001145102
NM_001145103
NM_001145104
NM_005902

NM_016769

NP_001138574
NP_001138575
NP_001138576
NP_005893

...
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