SKF-82958

SKF-82,958

Identifiers
IUPAC name 3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS Number	80751-65-1
PubChem CID	1225
ChemSpider	1188
ChEMBL	CHEMBL317741
Chemical and physical data
Formula	C19H20ClNO2
Molar mass	329.82 g/mol
3D model (Jmol)	Interactive image
SMILES C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl

SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D₁/D₅ receptor full agonist. SKF-82,958 and similar D₁-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.