SGCA

SGCA
Identifiers
Aliases	SGCA, 50-DAG, A2, ADL, DAG2, DMDA2, LGMD2D, SCARMD1, adhalin, 50DAG, sarcoglycan alpha
External IDs	MGI: 894698 HomoloGene: 9 GeneCards: SGCA
Gene ontology Molecular function • calcium ion binding • protein binding Cellular component • cytoplasm • integral component of membrane • membrane raft • dystroglycan complex • sarcolemma • plasma membrane • dystrophin-associated glycoprotein complex • cytoskeleton • membrane • cell-cell junction • sarcoglycan complex Biological process • muscle organ development • muscle contraction • membrane organization • response to denervation involved in regulation of muscle adaptation • skeletal muscle tissue regeneration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6442	20391
Ensembl	ENSG00000108823	ENSMUSG00000001508
UniProt	Q16586	P82350
RefSeq (mRNA)	NM_000023 NM_001135697	NM_009161
RefSeq (protein)	NP_000014 NP_001129169	NP_033187.1 NP_033187
Location (UCSC)	Chr 17: 50.16 – 50.18 Mb	Chr 11: 94.96 – 94.98 Mb
PubMed search

6442

20391

ENSG00000108823

ENSMUSG00000001508

Q16586

P82350

NM_000023
NM_001135697

NM_009161

NP_000014
NP_001129169

NP_033187.1
NP_033187

Alpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene.

The dystrophin-glycoprotein complex (DGC) comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Components of the DGC include dystrophin (MIM 300377), which is deficient in Duchenne muscular dystrophy (DMD; MIM 310200); syntrophins (e.g., MIM 600026); dystroglycans (MIM 128239); and sarcoglycans, such as adhalin, a 50-kD transmembrane protein (Roberds et al., 1993).[supplied by OMIM]

SGCA has been shown to interact with Biglycan.

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Wikipedia