Biglycan

BGN
Identifiers
Aliases	BGN, DSPG1, PG-S1, PGI, SLRR1A, biglycan
External IDs	OMIM: 301870 MGI: 88158 HomoloGene: 1293 GeneCards: BGN
Gene ontology Molecular function • protein kinase inhibitor activity • glycosaminoglycan binding • extracellular matrix structural constituent • extracellular matrix binding Cellular component • cytoplasm • extracellular matrix • proteinaceous extracellular matrix • intracellular • transport vesicle • extracellular region • cell surface • lysosomal lumen • Golgi lumen • sarcolemma • extracellular exosome • extracellular space Biological process • glycosaminoglycan metabolic process • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • chondroitin sulfate biosynthetic process • extracellular matrix organization • blood vessel remodeling • chondroitin sulfate catabolic process • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan • dermatan sulfate biosynthetic process • negative regulation of JAK-STAT cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	633	12111
Ensembl	ENSG00000182492	ENSMUSG00000031375
UniProt	P21810	P28653
RefSeq (mRNA)	NM_001711	NM_007542
RefSeq (protein)	NP_001702	NP_031568.2 NP_031568
Location (UCSC)	Chr X: 153.49 – 153.51 Mb	Chr X: 73.48 – 73.5 Mb
PubMed search

633

12111

ENSG00000182492

ENSMUSG00000031375

P21810

P28653

NM_001711

NM_007542

NP_001702

NP_031568.2
NP_031568

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome.

The name "biglycan" was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I).

Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective tissues. The CS/DS chains are attached at amino acids 5 and 10 in human biglycan. The composition of the GAG chains has been reported as varying according to tissue of origin. Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage.

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Wikipedia