SDHB

SDHB
Identifiers
Aliases	SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B
External IDs	OMIM: 185470 MGI: 1914930 HomoloGene: 2255 GeneCards: SDHB
Gene ontology Molecular function • ubiquinone binding • iron-sulfur cluster binding • metal ion binding • succinate dehydrogenase (ubiquinone) activity • protein binding • oxidoreductase activity • electron carrier activity • 2 iron, 2 sulfur cluster binding • 3 iron, 4 sulfur cluster binding • 4 iron, 4 sulfur cluster binding Cellular component • membrane • plasma membrane • nucleoplasm • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) • extracellular exosome • mitochondrial inner membrane • mitochondrion • mitochondrial membrane • respiratory chain complex II Biological process • succinate metabolic process • aerobic respiration • oxidation-reduction process • tricarboxylic acid cycle • respiratory electron transport chain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6390	67680
Ensembl	ENSG00000117118	ENSMUSG00000009863
UniProt	P21912	Q9CQA3
RefSeq (mRNA)	NM_003000	NM_023374
RefSeq (protein)	NP_002991	NP_075863.2 NP_075863
Location (UCSC)	Chr 1: 17.02 – 17.05 Mb	Chr 4: 140.96 – 140.98 Mb
PubMed search

6390

67680

ENSG00000117118

ENSMUSG00000009863

P21912

Q9CQA3

NM_003000

NM_023374

NP_002991

NP_075863.2
NP_075863

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene.

The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa.

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Wikipedia