Succinate dehydrogenase complex subunit C

SDHC
Identifiers
Aliases	SDHC, CYB560, CYBL, PGL3, QPS1, SDH3, succinate dehydrogenase complex subunit C
External IDs	OMIM: 602413 MGI: 1913302 HomoloGene: 2256 GeneCards: SDHC
Gene location (Human) Chr. Chromosome 1 (human) Band n/a Start 161,314,257 bp End 161,375,340 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band n/a Start 171,127,165 bp End 171,150,603 bp
Gene ontology Molecular function • electron carrier activity • oxidoreductase activity, acting on the CH-CH group of donors • succinate dehydrogenase activity • heme binding • metal ion binding Cellular component • integral component of membrane • mitochondrial inner membrane • respiratory chain complex II • succinate dehydrogenase complex • mitochondrion • membrane • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Biological process • aerobic respiration • tricarboxylic acid cycle • oxidation-reduction process • mitochondrial electron transport, succinate to ubiquinone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6391	66052
Ensembl	ENSG00000143252	ENSMUSG00000058076
UniProt	Q99643	Q9CZB0
RefSeq (mRNA)	NM_001035511 NM_001035512 NM_001035513 NM_001278172 NM_003001	NM_025321
RefSeq (protein)	NP_001030588 NP_001030589 NP_001030590 NP_001265101 NP_002992	NP_079597
Location (UCSC)	Chr 1: 161.31 – 161.38 Mb	Chr 1: 171.13 – 171.15 Mb
PubMed search

6391

66052

ENSG00000143252

ENSMUSG00000058076

Q99643

Q9CZB0

NM_001035511
NM_001035512
NM_001035513
NM_001278172
NM_003001

NM_025321

NP_001030588
NP_001030589
NP_001030590
NP_001265101
NP_002992

NP_079597

Succinate dehydrogenase complex subunit C, also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a protein that in humans is encoded by the SDHC gene. This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the . There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described.

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