Respiratory stimulant

Doxapram

Clinical data
Routes of administration	Intravenous
ATC code	R07AB01 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one
CAS Number	309-29-5 Y
PubChem CID	3156
DrugBank	DB00561 Y
ChemSpider	3044 Y
UNII	94F3830Q73
KEGG	D07873 Y
ChEBI	CHEBI:681848 Y
ChEMBL	CHEMBL1754 Y
ECHA InfoCard	100.005.653
Chemical and physical data
Formula	C24H30N2O2
Molar mass	378.507 g/mol
3D model (Jmol)	Interactive image
SMILES O=C4N(CC)CC(CCN1CCOCC1)C4(c2ccccc2)c3ccccc3
InChI InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 Y Key:XFDJYSQDBULQSI-UHFFFAOYSA-N Y

Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.

Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem.

Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections.

Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as buprenorphine or fentanyl analogues which may fail to respond adequately to treatment with naloxone.

It is equally effective as pethidine in suppressing shivering after surgery.

Side effects include high blood pressure, panic attacks, rapid heart rate, tremor, sweating and vomiting. Convulsions have been reported. Its use is relatively contraindicated in people with coronary heart disease, epilepsy, and high blood pressure. It is also contraindicated in newborns and small children, mainly due to the presence of benzyl alcohol, which is included as a preservative.