"Resistance" is a song by English alternative rock band Muse, featured on their fifth studio album The Resistance. Written by vocalist, guitarist and pianist Matthew Bellamy, it was released as the third single from the album, following "Uprising" and "Undisclosed Desires", on 22 February 2010. The song makes several references to the novel "1984", by George Orwell. The intro of the song is used in the trailer of the last episode of BBC show Silent Witness. In February 2010, Muse had uploaded a picture puzzle of "Resistance" artwork on their official Facebook page. The puzzle itself has a making of the "Resistance" track (which will be able to see it after solving the puzzle). This song was featured in a promo for an episode of Human Target. The song was also released as downloadable content for the music video game Guitar Hero: Warriors of Rock.

The music video for "Resistance", which features footage of the band performing live on The Resistance Tour, debuted on 14 January 2010, and was directed by Wayne Isham in Madrid (Palacio de los Deportes, 28-November-2009).

"Resistance" reached number 35 in the Triple J Hottest 100, 2009. On 22 February 2010, "Resistance" debuted at number 17 on the Hot30 Countdown. On 26 March 2010, "Resistance" debuted at number 20 on the VH1 Top 20 Video Countdown, peaking at #9.

The song was nominated at the 53rd Grammy Awards in two categories: Best Rock Performance by a Duo or Group with Vocal and Best Rock Song. It lost in both categories to Neil Young's "Angry World", and The Black Keys' "Tighten Up", respectively.

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