"Uprising" is a song by the English rock band Muse. It was released as the lead single from the band's fifth studio album, The Resistance, on 7 September 2009. The song was written by band member Matthew Bellamy, produced by the band themselves, and mixed by Mark 'Spike' Stent. "Uprising" had a very positive commercial performance, peaking within the top ten in seven countries. It was certified silver in the United Kingdom, gold in four countries, platinum in two countries, and double-platinum in the United States making it Muse's best selling single.

The title "Uprising" was first revealed on 3 July 2009, when the album's track listing was released sporadically on the band's Twitter page; the song was unveiled as the opening track of the album, preceding the title track "Resistance". In a pre-release review, French media source JudeBox described the song as follows:

Matt Bellamy’s voice is more serious and academic than usual. However it is delivered in a similar vein: Conspiracy, Apocalypse … He announces a “union”, speaks of “victory” that “they do not control.” Sound is still very heavy and dense, accompanied by mounted synthesizers. The structure of the song is simple for once.

"Uprising" is a synth-rock and glam rock song. The song is often considered to be partly inspired by the hit Blondie song "Call Me", because of the thumping bass line and the occasional lead guitar riff (Blondie have in turn referenced this in their 2010 live performances by singing the lyrics of "Call Me" whilst covering the music of "Uprising"). However, "Uprising" can be argued to have more in common with the Black Sabbath song "Children of the Grave" which Blondie's "Call Me" may have been based on. Many journalists have mentioned that "Uprising" is similar to the theme music for Doctor Who, and the 1988 hit single "Doctorin' the Tardis" by The KLF.

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