RHD (gene)

RHD
Identifiers
Aliases	RHD, CD240D, DIIIc, RH, RH30, RHCED, RHDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI, Rh blood group D antigen
External IDs	MGI: 1202882 HomoloGene: 7918 GeneCards: RHD
Gene ontology Molecular function • ammonium transmembrane transporter activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane Biological process • ammonium transport • organic cation transport • ammonium transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6007	19746
Ensembl	ENSG00000187010	ENSMUSG00000028825
UniProt	Q02161	Q8CF94
RefSeq (mRNA)	NM_001127691 NM_001282867 NM_001282868 NM_001282869 NM_001282870 NM_001282871 NM_001282872 NM_016124 NM_016225	NM_011270
RefSeq (protein)	NP_001121163 NP_001269796 NP_001269797 NP_001269798 NP_001269799 NP_001269800 NP_001269801 NP_057208	NP_035400.3 NP_035400
Location (UCSC)	Chr 1: 25.27 – 25.33 Mb	Chr 4: 134.86 – 134.9 Mb
PubMed search

6007

19746

ENSG00000187010

ENSMUSG00000028825

Q02161

Q8CF94

NM_001282871
NM_001282872
NM_016124
NM_016225

NM_011270

NP_001269800
NP_001269801
NP_057208

NP_035400.3
NP_035400

Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by the RHD gene.

The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits. RhAG is a functional ammonia transporter and is required for normal cell surface expression of RhD and RhCE. Patients who lack RhD/RhCE/RhAG on the surface of their erythrocytes have hemolytic anemia . Antibodies to the RhD protein can cause Rh disease.

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Wikipedia