RHAG

Identifiers

RHAG, CD241, RH2, RH50A, Rh50, Rh50GP, SLC42A1, OHS, OHST, Rh-associated glycoprotein

External IDs

MGI: 1202713 HomoloGene: 68045 GeneCards: RHAG

Gene ontology
Molecular function	• ankyrin binding • carbon dioxide transmembrane transporter activity • ammonium transmembrane transporter activity • leak channel activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• multicellular organismal iron ion homeostasis • bicarbonate transport • organic cation transport • carbon dioxide transport • erythrocyte development • transport • cellular ion homeostasis • carbon dioxide transmembrane transport • ammonium transport • monovalent inorganic cation transport • ammonium transmembrane transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6005


19743

Ensembl


ENSG00000112077


ENSMUSG00000023926

UniProt


Q02094


Q9QUT0

RefSeq (mRNA)


NM_000324


NM_011269

RefSeq (protein)


NP_000315


NP_035399.1 NP_035399

Location (UCSC)

Chr 6: 49.61 – 49.64 Mb

Chr 17: 40.81 – 40.84 Mb

PubMed search

NP_035399.1
NP_035399

Rh-associated glycoprotein (RHAG) is an ammonia transporter protein that in humans is encoded by the RHAG gene. RHAG has also recently been designated CD241 (cluster of differentiation 241). Mutations in the RHAG gene can cause .

The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein [supplied by OMIM].

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