RHAMM

HMMR
Identifiers
Aliases	HMMR, CD168, IHABP, RHAMM, Hyaluronan-mediated motility receptor, hyaluronan mediated motility receptor
External IDs	MGI: 104667 HomoloGene: 8271 GeneCards: HMMR
Gene location (Human) Chr. Chromosome 5 (human) Band 5q34 Start 163,460,203 bp End 163,491,945 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A5|11 24.4 cM Start 40,701,395 bp End 40,733,422 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • hyaluronic acid binding Cellular component • cytoplasm • cell surface • plasma membrane • membrane • cytosol Biological process • hyaluronan catabolic process • regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3161	15366
Ensembl	ENSG00000072571	ENSMUSG00000020330
UniProt	O75330	Q00547
RefSeq (mRNA)	NM_012485 NM_001142556 NM_001142557 NM_012484	NM_013552
RefSeq (protein)	NP_001136028 NP_001136029 NP_036616 NP_036617	NP_038580
Location (UCSC)	Chr 5: 163.46 – 163.49 Mb	Chr 11: 40.7 – 40.73 Mb
PubMed search

3161

15366

ENSG00000072571

ENSMUSG00000020330

O75330

Q00547

NM_012485
NM_001142556
NM_001142557
NM_012484

NM_013552

NP_001136028
NP_001136029
NP_036616
NP_036617

NP_038580

Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene. RHAMM recently has been also designated CD168 (cluster of differentiation 168).

RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan. RHAMM is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum / Golgi complex, RHAMM does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. RHAMM is localized inside the cell and is unconventionally exported to the cell surface in response to certain defined stimuli such as wounding and cytokines including TGF-β. The precise unconventional export mechanism for transporting RHAMM to the extracellular space is still unclear but may involve transport channels or proteins, flippase activity, or exocytosis, similar to other non-conventionally exported cell surface proteins such as BFGF1,2 and epimorphin.

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Wikipedia