RGMA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4UHY

Identifiers

Aliases

RGMA, RGM, repulsive guidance molecule family member a

External IDs

MGI: 2679262 HomoloGene: 10626 GeneCards: RGMA

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q26.1	Start	93,035,273 bp
Band	15q26.1	End	93,089,204 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 D1	Start	73,375,509 bp
Band	7\|7 D1	End	73,419,899 bp

Gene ontology
Molecular function	• transferrin receptor binding • protein binding • coreceptor activity
Cellular component	• anchored component of membrane • plasma membrane • extracellular exosome • endoplasmic reticulum • membrane
Biological process	• positive regulation of transcription from RNA polymerase II promoter • BMP signaling pathway • negative regulation of axon regeneration • regulation of neuron projection development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


56963


244058

Ensembl


ENSG00000182175


ENSMUSG00000070509

UniProt


Q96B86


Q6PCX7

RefSeq (mRNA)

NM_020211 NM_001166283 NM_001166286 NM_001166287 NM_001166288
NM_001166289


NM_177740

RefSeq (protein)

NP_001159755 NP_001159758 NP_001159759 NP_001159760 NP_001159761
NP_064596


NP_808408

Location (UCSC)

Chr 15: 93.04 – 93.09 Mb

Chr 15: 73.38 – 73.42 Mb

PubMed search

Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. In humans this protein is encoded by the RGMA gene.

RGMa is a repulsive guidance molecule for retinal axons. Furthermore, neogenin functions as a receptor for RGM. Neogenin overexpression and RGM downexpression in the developing embryonic neural tube induces apoptosis. The apoptotic activity of neogenin in the neural tube is associated with cleavage of its cytoplasmic domain by caspases.

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