BMPR2

BMPR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HLQ, 3G2F
Identifiers
Aliases	BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
External IDs	MGI: 1095407 HomoloGene: 929 GeneCards: BMPR2
Gene ontology Molecular function • signal transducer, downstream of receptor, with serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • ATP binding • protein serine/threonine kinase activity • activin receptor activity, type II • BMP binding • protein kinase activity • protein binding • kinase activity • growth factor binding • metal ion binding • nucleotide binding • transferase activity • BMP receptor activity Cellular component • integral component of membrane • caveola • spanning component of plasma membrane • dendrite • neuronal cell body • membrane • cell surface • integral component of plasma membrane • plasma membrane • cytoplasm • basal plasma membrane • apical plasma membrane • extracellular space • nucleoplasm • postsynaptic density • cell-cell adherens junction Biological process • endothelial cell apoptotic process • positive regulation of epithelial cell migration • transmembrane receptor protein serine/threonine kinase signaling pathway • negative regulation of vasoconstriction • positive regulation of endothelial cell proliferation • endochondral bone morphogenesis • positive regulation of endothelial cell migration • lymphangiogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • anterior/posterior pattern specification • regulation of cell proliferation • lung alveolus development • negative regulation of cell growth • transcription from RNA polymerase II promoter • regulation of lung blood pressure • protein phosphorylation • positive regulation of axon extension involved in axon guidance • artery development • blood vessel remodeling • BMP signaling pathway • mesoderm formation • vascular endothelial growth factor receptor signaling pathway • signal transduction by protein phosphorylation • proteoglycan biosynthetic process • positive regulation of cartilage development • maternal placenta development • endothelial cell proliferation • cellular response to starvation • negative regulation of DNA biosynthetic process • chondrocyte development • negative regulation of systemic arterial blood pressure • positive regulation of osteoblast differentiation • retina vasculature development in camera-type eye • cellular response to BMP stimulus • phosphorylation • venous blood vessel development • brain development • retina development in camera-type eye • positive regulation of BMP signaling pathway • limb development • positive regulation of bone mineralization • negative regulation of chondrocyte proliferation • lymphatic endothelial cell differentiation • mitral valve morphogenesis • pharyngeal arch artery morphogenesis • tricuspid valve morphogenesis • outflow tract septum morphogenesis • atrioventricular valve morphogenesis • activin receptor signaling pathway • cardiac muscle tissue development • outflow tract morphogenesis • endocardial cushion development • negative regulation of cell proliferation involved in heart valve morphogenesis • positive regulation of ossification • positive regulation of transcription from RNA polymerase II promoter • ventricular septum morphogenesis • atrial septum morphogenesis • semi-lunar valve development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	659	12168
Ensembl	ENSG00000204217	ENSMUSG00000067336
UniProt	Q13873	O35607
RefSeq (mRNA)	NM_001204 NM_033346	NM_007561
RefSeq (protein)	NP_001195	NP_031587.1 NP_031587
Location (UCSC)	Chr 2: 202.38 – 202.57 Mb	Chr 1: 59.76 – 59.88 Mb
PubMed search

2HLQ, 3G2F

659

12168

ENSG00000204217

ENSMUSG00000067336

Q13873

O35607

NM_001204
NM_033346

NM_007561

NP_001195

NP_031587.1
NP_031587

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signalling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates. The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.

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