ACVR2A

ACVR2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q4T, 3SOC, 4ASX
Identifiers
Aliases	ACVR2A, ACTRII, ACVR2, activin A receptor type 2A
External IDs	OMIM: 102581 MGI: 102806 HomoloGene: 20391 GeneCards: ACVR2A
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • PDZ domain binding • signal transducer, downstream of receptor, with serine/threonine kinase activity • growth factor binding • coreceptor activity • activin binding • metal ion binding • kinase activity • protein self-association • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • inhibin binding • protein binding • activin-activated receptor activity • ATP binding • BMP receptor activity Cellular component • cytoplasm • integral component of membrane • inhibin-betaglycan-ActRII complex • membrane • receptor complex • plasma membrane • integral component of plasma membrane • cell surface Biological process • positive regulation of protein phosphorylation • male gonad development • sperm ejaculation • signal transduction by protein phosphorylation • positive regulation of erythrocyte differentiation • positive regulation of bone mineralization • phosphorylation • positive regulation of pathway-restricted SMAD protein phosphorylation • gastrulation with mouth forming second • penile erection • regulation of nitric-oxide synthase activity • cellular response to BMP stimulus • Sertoli cell proliferation • BMP signaling pathway • embryonic skeletal system development • regulation of BMP signaling pathway • protein phosphorylation • determination of left/right symmetry • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of activin receptor signaling pathway • positive regulation of osteoblast differentiation • regulation of signal transduction • spermatogenesis • mesoderm development • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • activin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92	11480
Ensembl	ENSG00000121989	ENSMUSG00000052155
UniProt	P27037	P27038
RefSeq (mRNA)	NM_001278579 NM_001278580 NM_001616	NM_007396
RefSeq (protein)	NP_001265508 NP_001265509 NP_001607	NP_031422.3 NP_031422
Location (UCSC)	Chr 2: 147.84 – 147.93 Mb	Chr 2: 48.81 – 48.9 Mb
PubMed search

3Q4T, 3SOC, 4ASX

92

11480

ENSG00000121989

ENSMUSG00000052155

P27037

P27038

NM_001278579
NM_001278580
NM_001616

NM_007396

NP_001265508
NP_001265509
NP_001607

NP_031422.3
NP_031422

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor.

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