RANKL inhibitor

TNFSF11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3URF, 5BNQ
Identifiers
Aliases	TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11
External IDs	OMIM: 602642 MGI: 1100089 HomoloGene: 2744 GeneCards: TNFSF11
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.11 Start 42,562,736 bp End 42,608,013 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band n/a Start 78,277,445 bp End 78,308,043 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • tumor necrosis factor receptor superfamily binding • tumor necrosis factor receptor binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma • integral component of plasma membrane • extracellular region • extracellular space Biological process • mammary gland epithelial cell proliferation • cell differentiation • positive regulation of protein kinase B signaling • positive regulation of corticotropin-releasing hormone secretion • positive regulation of MAP kinase activity • calcium ion homeostasis • activation of JUN kinase activity • ossification • monocyte chemotaxis • cytokine-mediated signaling pathway • osteoclast differentiation • ERK1 and ERK2 cascade • paracrine signaling • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of osteoclast differentiation • tumor necrosis factor-mediated signaling pathway • positive regulation of intracellular signal transduction • positive regulation of bone resorption • mammary gland alveolus development • positive regulation of JNK cascade • bone resorption • positive regulation of osteoclast development • multicellular organism development • positive regulation of T cell activation • positive regulation of homotypic cell-cell adhesion • positive regulation of NF-kappaB transcription factor activity • positive regulation of fever generation by positive regulation of prostaglandin secretion • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling • regulation of osteoclast differentiation • immune response • animal organ morphogenesis • positive regulation of I-kappaB kinase/NF-kappaB signaling • TNFSF11-mediated signaling pathway • positive regulation of phosphorylation • protein homooligomerization • positive regulation of transcription from RNA polymerase II promoter • osteoclast proliferation • calcium-mediated signaling • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8600	21943
Ensembl	ENSG00000120659	ENSMUSG00000022015
UniProt	O14788	O35235
RefSeq (mRNA)	NM_003701 NM_033012	NM_011613
RefSeq (protein)	NP_003692 NP_143026	NP_035743
Location (UCSC)	Chr 13: 42.56 – 42.61 Mb	Chr 13: 78.28 – 78.31 Mb
PubMed search

3URF, 5BNQ

8600

21943

ENSG00000120659

ENSMUSG00000022015

O14788

O35235

NM_003701
NM_033012

NM_011613

NP_003692
NP_143026

NP_035743

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.

RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. Variation in concentration levels of RANKL throughout several organs, reconfirm the uses and importance of growth (particularly bone growth) and immune functions within the body.

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