Osteoprotegerin

TNFRSF11B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3URF
Identifiers
Aliases	TNFRSF11B, OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11b, TNF receptor superfamily member 11b
External IDs	OMIM: 602643 MGI: 109587 HomoloGene: 1912 GeneCards: TNFRSF11B
Gene ontology Molecular function • cytokine activity • tumor necrosis factor-activated receptor activity • receptor activity Cellular component • proteinaceous extracellular matrix • plasma membrane • integral component of plasma membrane • extracellular region • extracellular space Biological process • regulation of apoptotic process • skeletal system development • negative regulation of odontogenesis of dentin-containing tooth • response to nutrient • extracellular matrix organization • response to magnesium ion • tumor necrosis factor-mediated signaling pathway • response to arsenic-containing substance • response to estrogen • response to lipopolysaccharide • regulation of cell proliferation • immune response • response to inorganic substance • apoptotic signaling pathway • inflammatory response • response to drug • signal transduction • negative regulation of bone resorption • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4982	18383
Ensembl	ENSG00000164761	ENSMUSG00000063727
UniProt	O00300	O08712
RefSeq (mRNA)	NM_002546	NM_008764
RefSeq (protein)	NP_002537	NP_032790.3 NP_032790
Location (UCSC)	Chr 8: 118.92 – 118.95 Mb	Chr 15: 54.25 – 54.28 Mb
PubMed search

3URF

4982

18383

ENSG00000164761

ENSMUSG00000063727

O00300

O08712

NM_002546

NM_008764

NP_002537

NP_032790.3
NP_032790

Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF), or tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a protein that in humans is encoded by the TNFRSF11B gene. Osteoprotegerin is a cytokine receptor, and a member of the tumor necrosis factor (TNF) receptor superfamily.

Osteoprotegerin is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60-kDa monomer or 120-kDa dimer linked by disulfide bonds.

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Wikipedia