RANK

TNFRSF11A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LB5
Identifiers
Aliases	TNFRSF11A, tumor necrosis factor receptor superfamily, member 11a, NFKB activator, CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNF receptor superfamily member 11a
External IDs	OMIM: 603499 MGI: 1314891 HomoloGene: 2848 GeneCards: TNFRSF11A
Gene ontology Molecular function • metal ion binding • protein binding • tumor necrosis factor-activated receptor activity • transmembrane signaling receptor activity • receptor activity • cytokine binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell surface • external side of plasma membrane • cytosol • plasma membrane Biological process • regulation of apoptotic process • response to cytokine • response to interleukin-1 • adaptive immune response • ossification • monocyte chemotaxis • circadian temperature homeostasis • positive regulation of JUN kinase activity • osteoclast differentiation • cell-cell signaling • positive regulation of sequence-specific DNA binding transcription factor activity • tumor necrosis factor-mediated signaling pathway • mammary gland alveolus development • multicellular organism development • response to tumor necrosis factor • response to lipopolysaccharide • positive regulation of NF-kappaB transcription factor activity • positive regulation of fever generation by positive regulation of prostaglandin secretion • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling • positive regulation of cell proliferation • apoptotic signaling pathway • response to radiation • TNFSF11-mediated signaling pathway • inflammatory response • lymph node development • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8792	21934
Ensembl	ENSG00000141655	ENSMUSG00000026321
UniProt	Q9Y6Q6	O35305
RefSeq (mRNA)	NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839	NM_009399
RefSeq (protein)	NP_001257878 NP_001257879 NP_001257880 NP_001265197 NP_003830	NP_033425.3 NP_033425
Location (UCSC)	Chr 18: 62.33 – 62.39 Mb	Chr 1: 105.78 – 105.85 Mb
PubMed search

1LB5

8792

21934

ENSG00000141655

ENSMUSG00000026321

Q9Y6Q6

O35305

NM_001270949
NM_001270950
NM_001270951
NM_001278268
NM_003839

NM_009399

NP_001257878
NP_001257879
NP_001257880
NP_001265197
NP_003830

NP_033425.3
NP_033425

Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor or TNFRSF11A, is a member of the tumor necrosis factor receptor (TNFR) molecular sub-family. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. Osteoprotegerin (OPG) is a decoy receptor for RANK, and regulates the stimulation of the RANK signaling pathway by competing for RANKL. The cytoplasmic domain of RANK binds TRAFs 1, 2, 3, 5, and 6 which transmit signals to downstream targets such as NF-κB and JNK.

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Wikipedia