Publius Sestius was a Roman senator in the 1st century BC. He was a praetor in 53 BC, as well as a friend and ally of Cicero, by whom he was defended in 56 BC. Upon the outbreak of Caesar's Civil War he joined the party of Pompey, having become the governor of Cilicia. According to Plutarch's Life of Brutus he was accompanied by Marcus Brutus to his province, but Sestius subsequently went over to Caesar, who sent him into Cappadocia in 48 BC.
This article incorporates text from a publication now in the public domain: Smith, William, ed. (1870). "". Dictionary of Greek and Roman Biography and Mythology.