Polyketide

Polyketides are a class of secondary metabolites produced by certain living organisms in order to impart to them some survival advantage. Many mycotoxins produced by fungi are polyketides.

Structurally, polyketides are complex organic compounds that are often highly active biologically. Many pharmaceuticals are derived from or inspired by polyketides.

Geldanamycin, a useful antibiotic.

Doxycycline, another important antibiotic.

Erythromycin, an antibiotic.

Aflatoxin B1 one of the most carcinogenic compounds known.

Polyketides are usually biosynthesized through the decarboxylative condensation of malonyl-CoA derived extender units in a similar process to fatty acid synthesis (a Claisen condensation). The polyketide chains produced by a minimal polyketide synthase are often further derivitized and modified into bioactive natural products.

Polyketides are structurally a very diverse family of natural products with diverse biological activities and pharmacological properties. They are broadly divided into three classes: type I polyketides (often macrolides produced by multimodular megasynthases), type II polyketides (often aromatic molecules produced by the iterative action of dissociated enzymes), and type III polyketides (often small aromatic molecules produced by fungal species). Polyketide antibiotics, antifungals, cytostatics, anticholesteremic, antiparasitics, coccidiostats, animal growth promoters and natural insecticides are in commercial use.

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