Plasminogen activator inhibitor-2

SERPINB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ARR, 1BY7, 1JRR, 2ARQ
Identifiers
Aliases	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
External IDs	OMIM: 173390 MGI: 97609 HomoloGene: 20571 GeneCards: SERPINB2
Gene ontology Molecular function • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • extracellular region • plasma membrane • extracellular space • cytoplasm Biological process • negative regulation of peptidase activity • wound healing • negative regulation of apoptotic process • fibrinolysis • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5055	18788
Ensembl	ENSG00000197632	ENSMUSG00000062345
UniProt	P05120	P12388
RefSeq (mRNA)	NM_002575 NM_001143818	NM_001174170 NM_011111
RefSeq (protein)	NP_001137290 NP_002566	NP_001167641.1 NP_035241.1 NP_001167641 NP_035241
Location (UCSC)	Chr 18: 63.87 – 63.9 Mb	Chr 1: 107.51 – 107.54 Mb
PubMed search

2ARR, 1BY7, 1JRR, 2ARQ

5055

18788

ENSG00000197632

ENSMUSG00000062345

P05120

P12388

NM_002575
NM_001143818

NM_001174170
NM_011111

NP_001137290
NP_002566

NP_001167641.1
NP_035241.1
NP_001167641
NP_035241

Plasminogen activator inhibitor-2 (placental PAI), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

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