Urokinase

PLAU
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C5W, 1C5X, 1C5Y, 1C5Z, 1EJN, 1F5K, 1F5L, 1F92, 1FV9, 1GI7, 1GI8, 1GI9, 1GJ7, 1GJ8, 1GJ9, 1GJA, 1GJB, 1GJC, 1GJD, 1KDU, 1LMW, 1O3P, 1O5A, 1O5B, 1O5C, 1OWD, 1OWE, 1OWH, 1OWI, 1OWJ, 1OWK, 1SC8, 1SQA, 1SQO, 1SQT, 1U6Q, 1VJA, 1W0Z, 1W10, 1W11, 1W12, 1W13, 1W14, 2FD6, 2NWN, 2O8T, 2O8U, 2O8W, 2R2W, 2VIN, 2VIO, 2VIP, 2VIQ, 2VIV, 2VIW, 2VNT, 3BT1, 3BT2, 3IG6, 3KGP, 3KHV, 3KID, 3M61, 3MHW, 3MWI, 3OX7, 3OY5, 3OY6, 3QN7, 3U73, 4DVA, 4DW2, 4FU7, 4FU8, 4FU9, 4FUB, 4FUC, 4FUD, 4FUE, 4FUF, 4FUG, 4FUH, 4FUI, 4FUJ, 4GLY, 4H42, 4JK5, 4JK6, 1URK, 4JNI, 4JNL, 4K24, 4MNV, 4MNW, 4MNX, 4MNY, 4OS1, 4OS2, 4OS4, 4OS5, 4OS6, 4OS7, 4X1N, 4X1Q, 4X1R, 4ZHL, 4ZHM, 4X0W, 4X1P, 4XSK, 4X1S, 5HGG, 4ZKO, 2I9B, 4ZKR, 4ZKS, 2I9A, 4ZKN
Identifiers
Aliases	PLAU, uPA, Urokinase-type plasminogen activator, Kinlytic, Abbokinase, ATF, BDPLT5, QPD, UPA, URK, u-PA, plasminogen activator, urokinase
External IDs	OMIM: 191840 MGI: 97611 HomoloGene: 55670 GeneCards: PLAU
Gene ontology Molecular function • peptidase activity • hydrolase activity • serine-type peptidase activity • protein binding • serine-type endopeptidase activity Cellular component • extracellular exosome • extracellular region • focal adhesion • cell surface • plasma membrane • extracellular space • specific granule membrane • tertiary granule membrane Biological process • response to hypoxia • signal transduction • regulation of cell proliferation • smooth muscle cell migration • regulation of wound healing • chemotaxis • regulation of cell adhesion mediated by integrin • regulation of smooth muscle cell migration • regulation of receptor activity • hemostasis • regulation of smooth muscle cell-matrix adhesion • fibrinolysis • blood coagulation • positive regulation of cell migration • proteolysis • neutrophil degranulation • plasminogen activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5328	18792
Ensembl	ENSG00000122861	ENSMUSG00000021822
UniProt	P00749	P06869
RefSeq (mRNA)	NM_001145031 NM_002658 NM_001319191	NM_008873
RefSeq (protein)	NP_001138503 NP_001306120 NP_002649	NP_032899.1 NP_032899
Location (UCSC)	Chr 10: 73.91 – 73.92 Mb	Chr 14: 20.84 – 20.84 Mb
PubMed search

Urokinase

Clinical data
AHFS/Drugs.com	Monograph
ATC code	B01AD04 (WHO)
Identifiers
CAS Number	9039-53-6 Y
DrugBank	DB00013 N
ChemSpider	none
UNII	83G67E21XI
KEGG	D03341 Y
ChEMBL	CHEMBL1201420 N
ECHA InfoCard	100.029.913
Chemical and physical data
Formula	C1376H2145N383O406S18
Molar mass	31126.5 g/mol
NY (what is this?)

1C5W, 1C5X, 1C5Y, 1C5Z, 1EJN, 1F5K, 1F5L, 1F92, 1FV9, 1GI7, 1GI8, 1GI9, 1GJ7, 1GJ8, 1GJ9, 1GJA, 1GJB, 1GJC, 1GJD, 1KDU, 1LMW, 1O3P, 1O5A, 1O5B, 1O5C, 1OWD, 1OWE, 1OWH, 1OWI, 1OWJ, 1OWK, 1SC8, 1SQA, 1SQO, 1SQT, 1U6Q, 1VJA, 1W0Z, 1W10, 1W11, 1W12, 1W13, 1W14, 2FD6, 2NWN, 2O8T, 2O8U, 2O8W, 2R2W, 2VIN, 2VIO, 2VIP, 2VIQ, 2VIV, 2VIW, 2VNT, 3BT1, 3BT2, 3IG6, 3KGP, 3KHV, 3KID, 3M61, 3MHW, 3MWI, 3OX7, 3OY5, 3OY6, 3QN7, 3U73, 4DVA, 4DW2, 4FU7, 4FU8, 4FU9, 4FUB, 4FUC, 4FUD, 4FUE, 4FUF, 4FUG, 4FUH, 4FUI, 4FUJ, 4GLY, 4H42, 4JK5, 4JK6, 1URK, 4JNI, 4JNL, 4K24, 4MNV, 4MNW, 4MNX, 4MNY, 4OS1, 4OS2, 4OS4, 4OS5, 4OS6, 4OS7, 4X1N, 4X1Q, 4X1R, 4ZHL, 4ZHM, 4X0W, 4X1P, 4XSK, 4X1S, 5HGG, 4ZKO, 2I9B, 4ZKR, 4ZKS, 2I9A, 4ZKN

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