Pituitary adenylyl cyclase-activating peptide

ADCYAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GEA, 2D2P, 2JOD
Identifiers
Aliases	ADCYAP1, PACAP, adenylate cyclase activating polypeptide 1
External IDs	OMIM: 102980 MGI: 105094 HomoloGene: 869 GeneCards: ADCYAP1
Gene ontology Molecular function • signal transducer activity, downstream of receptor • pituitary adenylate cyclase activating polypeptide activity • hormone activity • peptide hormone receptor binding • protein binding • pituitary adenylate cyclase-activating polypeptide receptor binding • neuropeptide hormone activity • receptor binding Cellular component • intracellular • extracellular region • terminal bouton • extracellular space Biological process • histamine secretion • positive regulation of cAMP biosynthetic process • pituitary gland development • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of glial cell proliferation • female pregnancy • cell-cell signaling • negative regulation of cell cycle • negative regulation of muscle cell apoptotic process • behavioral fear response • nervous system development • activation of adenylate cyclase activity • regulation of protein localization • positive regulation of GTPase activity • ATP metabolic process • negative regulation of acute inflammatory response to non-antigenic stimulus • regulation of oligodendrocyte progenitor proliferation • cellular response to glucocorticoid stimulus • positive regulation of gene expression • negative regulation of GTPase activity • positive regulation of synaptic transmission, glutamatergic • positive regulation of chemokine (C-C motif) ligand 5 production • regulation of postsynaptic membrane potential • positive regulation of cell proliferation • negative regulation of potassium ion transport • positive regulation of ERK1 and ERK2 cascade • positive regulation of interleukin-6 production • positive regulation of neuron projection development • response to starvation • ovarian follicle development • sensory perception of pain • response to ethanol • negative regulation of acute inflammatory response to antigenic stimulus • neuropeptide signaling pathway • neuron projection development • cAMP-mediated signaling • positive regulation of somatostatin secretion • positive regulation of transcription from RNA polymerase II promoter • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • positive regulation of protein kinase activity • regulation of protein phosphorylation • positive regulation of adenylate cyclase activity • positive regulation of cytosolic calcium ion concentration • insulin secretion • positive regulation of growth hormone secretion • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	116	11516
Ensembl	ENSG00000141433	ENSMUSG00000024256
UniProt	P18509	O70176
RefSeq (mRNA)	NM_001099733 NM_001117	NM_009625 NM_001315503 NM_001315504
RefSeq (protein)	NP_001093203 NP_001108	NP_001302432 NP_001302433 NP_033755
Location (UCSC)	Chr 18: 0.9 – 0.91 Mb	Chr 17: 93.2 – 93.21 Mb
PubMed search

1GEA, 2D2P, 2JOD

116

11516

ENSG00000141433

ENSMUSG00000024256

P18509

O70176

NM_001099733
NM_001117

NM_009625
NM_001315503
NM_001315504

NP_001093203
NP_001108

NP_001302432
NP_001302433
NP_033755

Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the PACAP receptor.

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