Vasoactive intestinal peptide

VIP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2RRI, 2RRH

Identifiers

VIP, PHM27, vasoactive intestinal peptide

External IDs

Gene ontology
Molecular function	• hormone activity • protein binding • neuropeptide hormone activity
Cellular component	• extracellular region
Biological process	• G-protein coupled receptor signaling pathway • response to yeast • body fluid secretion • prolactin secretion • antibacterial humoral response • mRNA stabilization • defense response to Gram-negative bacterium • positive regulation of cell proliferation • innate immune response • antifungal humoral response • defense response to Gram-positive bacterium • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • positive regulation of protein catabolic process • regulation of protein localization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7432


22353


ENSG00000146469


ENSMUSG00000019772


P01282


P32648

RefSeq (mRNA)


NM_003381 NM_194435


NM_011702 NM_001313969

RefSeq (protein)


NP_003372 NP_919416


NP_001300898.1 NP_035832.1 NP_001300898 NP_035832

Location (UCSC)

PubMed search

Vasoactive intestinal peptide, also known as the vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a neuropeptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors. VIP is produced in many tissues of vertebrates including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain. VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.