Peroxisome proliferator-activated receptor alpha

PPARA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT

Identifiers

Aliases

PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha

External IDs

MGI: 104740 HomoloGene: 21047 GeneCards: PPARA

Targeted by Drug

bezafibrate, ciprofibrate, clofibrate, farglitazar, fenofibrate, gemfibrozil, oleic monoethanolamide, pirinixic acid

Gene ontology
Molecular function	• NFAT protein binding • receptor activity • DNA binding • sequence-specific DNA binding • phosphatase binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • protein complex binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • MDM2/MDM4 family protein binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • steroid hormone receptor activity • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • drug binding • RNA polymerase II repressing transcription factor binding • transcription coactivator binding • ubiquitin conjugating enzyme binding • lipid binding • transcription factor binding
Cellular component	• nucleus • nucleoplasm
Biological process	• lipoprotein metabolic process • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of fatty acid beta-oxidation • negative regulation of glycolytic process • response to hypoxia • regulation of transcription, DNA-templated • cellular lipid metabolic process • negative regulation of blood pressure • lipid metabolic process • rhythmic process • negative regulation of receptor biosynthetic process • wound healing • negative regulation of leukocyte cell-cell adhesion • negative regulation of transcription from RNA polymerase II promoter • fatty acid transport • negative regulation of protein binding • negative regulation of appetite • circadian regulation of gene expression • transcription, DNA-templated • fatty acid metabolic process • behavioral response to nicotine • positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • response to insulin • heart development • intracellular receptor signaling pathway • negative regulation of transcription regulatory region DNA binding • negative regulation of sequestering of triglyceride • regulation of circadian rhythm • regulation of fatty acid metabolic process • epidermis development • regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter • regulation of gene expression • enamel mineralization • positive regulation of gluconeogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • negative regulation of macrophage derived foam cell differentiation • regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter • regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • negative regulation of neuron death • positive regulation of fatty acid oxidation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5465


19013

Ensembl


ENSG00000186951


ENSMUSG00000022383

UniProt


Q07869 Q86SF0


P23204

RefSeq (mRNA)


NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644


NM_001113418 NM_011144

RefSeq (protein)


NP_001001928 NP_005027


NP_001106889.1 NP_035274.2 NP_001106889 NP_035274

Location (UCSC)

Chr 22: 46.15 – 46.24 Mb

Chr 15: 85.73 – 85.8 Mb

PubMed search

1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT

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