Patrizia Ciofi (born 7 June 1967) is an Italian operatic Coloratura soprano .
Born in Casole d'Elsa, Siena, she studied at the Istituto Musicale Pietro Mascagni in Livorno. She subsequently took part in master classes at the Accademia Musicale Chigiana, Siena, with Carlo Bergonzi and Shirley Verrett. She made her debut in Gino Negri’s Giovanni Sebastiano at the Teatro Comunale, Florence, and her La Scala debut in 1997 with La traviata, conducted by Riccardo Muti, and she returned to La Scala in L'elisir d'amore in 1997 and 2001. She has sung in most of the major Italian opera houses as well as the Rossini Festival in Pesaro and at the Martina Franca Festival.
She has also sung in Paris, at the Châtelet, the Opéra de Paris and the Théâtre des Champs-Elysées, in Lyon and Marseille, also sung in Barcelona, at the Gran Teatre del Liceu. She made her Covent Garden debut in 2002 with Rigoletto, her Chicago debut in 2003 with La Traviata and Wiener Staatsoper debut in 2008 with La Sonnambula.