Parathyroid hormone 2 receptor

PTH2R
Identifiers
Aliases	PTH2R, PTHR2, parathyroid hormone 2 receptor
External IDs	MGI: 2180917 HomoloGene: 3701 GeneCards: PTH2R
Gene ontology Molecular function • protein binding • G-protein coupled receptor activity • parathyroid hormone receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5746	213527
Ensembl	ENSG00000144407	ENSMUSG00000025946
UniProt	P49190	Q91V95
RefSeq (mRNA)	NM_001309516 NM_005048	NM_139270
RefSeq (protein)	NP_001296445 NP_005039	NP_644676
Location (UCSC)	Chr 2: 208.36 – 208.85 Mb	Chr 1: 65.28 – 65.39 Mb
PubMed search

5746

213527

ENSG00000144407

ENSMUSG00000025946

P49190

Q91V95

NM_001309516
NM_005048

NM_139270

NP_001296445
NP_005039

NP_644676

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding

...
Wikipedia