Parathyroid hormone 1 receptor

PTH1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BL1, 3C4M, 3H3G, 3L2J, 4Z8J
Identifiers
Aliases	PTH1R, PFE, PTHR, PTHR1, Parathyroid hormone 1 receptor
External IDs	MGI: 97801 HomoloGene: 267 GeneCards: PTH1R
Gene ontology Molecular function • G-protein coupled receptor activity • parathyroid hormone receptor activity • signal transducer activity • protein self-association • peptide hormone binding • protein binding • transmembrane signaling receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • receptor complex • plasma membrane • intracellular • brush border membrane • basolateral plasma membrane • apical plasma membrane • extracellular exosome • nucleus • integral component of plasma membrane Biological process • skeletal system development • G-protein coupled receptor signaling pathway • bone mineralization • chondrocyte differentiation • ossification • positive regulation of inositol phosphate biosynthetic process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • aging • cellular calcium ion homeostasis • cell maturation • bone resorption • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • positive regulation of cell proliferation • osteoblast development • signal transduction • negative regulation of cell proliferation • adenylate cyclase-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5745	19228
Ensembl	ENSG00000160801	ENSMUSG00000032492
UniProt	Q03431	P41593
RefSeq (mRNA)	NM_000316 NM_001184744	NM_001083935 NM_001083936 NM_011199
RefSeq (protein)	NP_000307 NP_001171673	NP_001077404.1 NP_001077405.1 NP_035329.2 NP_001077404 NP_001077405 NP_035329
Location (UCSC)	Chr 3: 46.88 – 46.9 Mb	Chr 9: 110.72 – 110.75 Mb
PubMed search

1BL1, 3C4M, 3H3G, 3L2J, 4Z8J

5745

19228

ENSG00000160801

ENSMUSG00000032492

Q03431

P41593

NM_000316
NM_001184744

NM_001083935
NM_001083936
NM_011199

NP_000307
NP_001171673

NP_035329

Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).

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