The Palace of San Telmo (Spanish: Palacio de San Telmo) is a historical edifice in Seville, southern Spain, now the seat of the presidency of the Andalusian Autonomous Government. Construction of the building began in 1682 outside the walls of the city, on property belonging to the Tribunal of the Holy Office, the institution responsible for the Spanish Inquisition. It was originally constructed as the seat of the Seminary School of the University of Navigators (Colegio Seminario de la Universidad de Mareantes), a school of orphan children of sailors.
The palace is one of the emblematic buildings of Sevillian Baroque architecture. It is built on a rectangular plan, with several interior courtyards, including a central courtyard, towers on the four corners, a chapel, and gardens. The exuberantly baroque chapel, accessed from one of the courtyards, is the work of architect Leonardo de Figueroa; among those involved in its decoration were sculptor Pedro Duque y Cornejo, stonecutter Miguel de Quintana, painter Domingo Martínez, and carpenter Juan Tomás Díaz. Presiding over the chapel is an early 17th century statue of Nuestra Señora del Buen Aire ("Our Lady of Good Air").
The principal façade of the palace is distinguished by the magnificent Churrigueresque entrance completed in 1754, the work of other members of the Figueroa family, specifically Matías and Antonio Matías, son and grandson of Leonardo de Figueroa, at a cost of 50,000 pesos. The entryway consists of several parts. The door is flanked by three columns on each side. Over the door is a balcony supported by Atlantes (supports sculpted in the form of a man) with aspects of indigenous people of the Americas; twelve allegorical female figures represent the nautical arts and sciences. Finally, there is a sculptural grouping with columns and a figure of Peter González, Saint Telmo (or Elmo), patron saint of sailors, flanked by the patron saints of the city: Saint Ferdinand (Ferdinand III of Castile) and Saint Hermenegild.