PSD-95

DLG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KEF, 3I4W, 3K82, 3ZRT
Identifiers
Aliases	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4
External IDs	MGI: 1277959 HomoloGene: 1047 GeneCards: DLG4
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,189,890 bp End 7,219,702 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 70,017,085 bp End 70,045,532 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • beta-1 adrenergic receptor binding • PDZ domain binding • protein complex binding • scaffold protein binding • guanylate kinase activity • P2Y1 nucleotide receptor binding • acetylcholine receptor binding • kinase binding • protein C-terminus binding • protein binding • ionotropic glutamate receptor binding • D1 dopamine receptor binding • protein phosphatase binding • neuroligin family protein binding • ligand-gated ion channel activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • juxtaparanode region of axon • endocytic vesicle membrane • synaptic membrane • postsynaptic membrane • cell projection • membrane • postsynaptic density • synaptic vesicle • extrinsic component of cytoplasmic side of plasma membrane • voltage-gated potassium channel complex • cortical cytoskeleton • plasma membrane • dendritic spine • synapse • excitatory synapse • cerebellar mossy fiber • axon • cell junction • dendrite • basolateral plasma membrane • endoplasmic reticulum • neuron spine • AMPA glutamate receptor complex • dendrite cytoplasm • ionotropic glutamate receptor complex • neuron projection terminus • cell periphery • cytosol • postsynaptic density membrane • postsynapse Biological process • receptor localization to synapse • regulation of grooming behavior • regulation of long-term neuronal synaptic plasticity • neuromuscular process controlling balance • protein complex assembly • negative regulation of receptor internalization • establishment of protein localization • positive regulation of cytosolic calcium ion concentration • learning • nervous system development • MAPK cascade • locomotory exploration behavior • regulation of NMDA receptor activity • AMPA glutamate receptor clustering • dendritic spine morphogenesis • vocalization behavior • positive regulation of synaptic transmission • establishment or maintenance of epithelial cell apical/basal polarity • positive regulation of excitatory postsynaptic potential • social organism behavior • synaptic vesicle maturation • protein localization to synapse • signal transduction • GMP metabolic process • GDP metabolic process • chemical synaptic transmission • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1742	13385
Ensembl	ENSG00000132535	ENSMUSG00000020886
UniProt	P78352 O14909	Q62108
RefSeq (mRNA)	NM_001128827 NM_001365 NM_001321074 NM_001321075 NM_001321076 NM_001321077	NM_001109752 NM_007864
RefSeq (protein)	NP_001122299 NP_001308003 NP_001308004 NP_001308005 NP_001308006 NP_001356	NP_001103222 NP_031890
Location (UCSC)	Chr 17: 7.19 – 7.22 Mb	Chr 17: 70.02 – 70.05 Mb
PubMed search

1KEF, 3I4W, 3K82, 3ZRT

1742

13385

ENSG00000132535

ENSMUSG00000020886

P78352
O14909

Q62108

NM_001321077

NM_001109752
NM_007864

NP_001356

NP_001103222
NP_031890

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.

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